Be comfortable with uncertainty

I quote from Eckhart Tolle:

When you become comfortable with uncertainty, infinite possibilities open up in your life. It means fear is no longer a dominant factor in what you do and no longer prevents you from taking action to initiate change. The Roman philosopher Tacitus rightly observed that ‘the desire for safety stands against every great and noble enterprise.’ If uncertainty is unacceptable to you, it turns into fear. If it is perfectly acceptable, it turns into aliveness, alertness and creativity.

I especially like this sentence, "the desire for safety stands against every great and noble enterprise". Is this a sign for me? Hmm...